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One element in micrograms, one metabolism in kilojoules

This page gathers what can be expressed about iodine in numbers: the content of common servings, the recommendations of professional societies by stage of life, the path of the element between the gut and glandular tissue, and the official wording of the three claims authorized for it in the European Union.


How the wording comes about

Health claims in the European Union cannot be worded freely. Regulation (EC) No 1924/2006 sets the framework, and Regulation (EU) No 432/2012 lists, in an annex, the sentences that may be used. Anyone who wants to use a sentence that does not appear there may not use it — not even if it would be factually correct. This structure explains why the wording sounds so uniform: it is the result of an authorization procedure, not the result of editorial writing.

The substance is authorized, a product is advertised

A common misunderstanding concerns who the authorization applies to. What is approved is always a nutrient, in this case the element iodine, and not a tablet, a powder or a brand. A product may carry the sentence if it contains the prescribed amount of the nutrient; the authorization says nothing about the quality of that product, its manufacture or its price. Two packages with an identical claim can differ in every other respect.

The minimum amount without which the sentence may not be used

Every authorized claim is tied to a condition. It requires that a food supply at least a certain amount of the nutrient — usually 15 percent of the reference value, per 100 grams, 100 milliliters or one serving. For iodine, the labeling reference value is 150 micrograms per day, so the threshold is around 22.5 micrograms. If it is not reached, the sentence remains inadmissible, however accurate it may be in general.

The reference value itself is not a personal target. It comes from the Food Information Regulation and serves to make percentage figures on packaging comparable. The recommendations of professional societies differ from it, in both directions — the second section returns to this.


Ten servings and their measured contents

The following list gives approximate values for typical serving sizes. They come from nutrition databases and describe averages, not guaranteed contents. The range is striking: a fish dish and a side dish differ by a factor of fifty.

Approximate iodine content of common servings
FoodServingIodine (rounded)
Haddock, cooked150 gapprox. 350 µg
Cod, cooked150 gapprox. 250 µg
Pollock, cooked150 gapprox. 200 µg
Blue mussels100 gapprox. 130 µg
Iodized table salt1 gapprox. 20 µg
Cow's milk200 mlapprox. 20 µg
Mixed rye bread with iodized salt50 gapprox. 10 µg
Quark100 gapprox. 8 µg
Chicken egg60 gapprox. 6 µg
Potatoes, cooked200 gapprox. 6 µg

Rounding is intentional. Individual measurements vary considerably.

Why two servings of the same food can differ

In saltwater fish, the content depends on the species, the fishing area and the preparation; when cooked in water, part of it passes into the liquid, which is usually poured away afterwards. In milk and dairy products, the element does not come from the soil but from the animals' feed and from disinfectants used in milking operations — so the value varies between farms and over the course of the year. In bread and cured meats, on the other hand, the use of iodized salt is a manufacturer's decision that is not always visible on the package.

That is why tables of this kind are useful for comparing orders of magnitude and of only limited use for calculating a personal daily amount.

What expert bodies state for different stages of life

Alongside the EU labeling value are the estimated values of the German-speaking professional societies. They are graded by age and, for adults, are higher than the value on the package.

Intake values compared, per day
GroupSource of the figureValue
Food labelingEU reference value150 µg
Children, 4 to 7 yearsEstimated value, professional societies120 µg
Children, 7 to 10 yearsEstimated value, professional societies140 µg
Adolescents, 13 to 18 yearsEstimated value, professional societies200 µg
Adults, 19 to 50 yearsEstimated value, professional societies200 µg
Adults aged 51 and overEstimated value, professional societies180 µg
Pregnant womenEstimated value, professional societies230 µg
Breastfeeding womenEstimated value, professional societies260 µg

Two sets of figures with different purposes: one serves labeling, the other nutrition planning for groups.


What happens to the element between the gut and the gland

From the serving to the site of action there are only a few stations, and none of them is particularly spectacular. What is remarkable, rather, is the tenacity with which the body holds on to an ion that is present in the blood only in tiny concentrations.

A transporter that works against the gradient

The cells of the glandular tissue carry a protein in their membrane that moves iodide together with sodium into the cell interior. The process runs against the concentration gradient and therefore costs energy, which comes from the sodium gradient. In this way the tissue reaches a concentration many times higher than that in blood plasma. The same transport protein is also found, to a lesser extent, in the salivary glands, the stomach lining and the mammary gland.

Why the tissue does not need to renew its supply every day

Inside the gland, the element is bound to a large protein and stored in a viscous mass between the cells. This design allows for a reserve that lasts several weeks — a notable difference from elements whose supply must be replenished daily. When needed, two messenger substances are released from the reserve that differ only in the number of iodine atoms they contain: four in one, three in the other.

The second of the three authorized sentences refers to exactly this tissue. Iodine contributes to the normal function of the thyroid gland — In accordance with Regulation (EU) No 432/2012. It describes the maintenance of a usual state and makes no statement about laboratory values or diseases of this organ.


From hormone to a changed transcription rate

The two messenger substances leave the glandular tissue via the blood, bound to transport proteins. Only a very small free portion passes into the cells of the target tissues. That is where the part of the process begins to which the first of the three claims refers.

Receptors that already sit on the genome

Unlike many hormones, these messenger substances do not dock at the cell surface but at receptors in the cell nucleus that are already bound to specific sections of the genome. When the messenger arrives, the receptor changes its shape and thus its relationship to the surrounding transcription machinery. The result is not an immediate reaction but a changed rate at which certain genes are read — an effect that takes hours to days to show up in the makeup of the cell.

Oxygen consumption as a measure of turnover

The genes whose transcription rate is influenced in this way include those for enzymes of the respiratory chain and for ion pumps in the cell membrane. Both are major ongoing items in the energy budget. In physiology, the turnover of a tissue is therefore measured by its oxygen consumption: if you know how much oxygen is consumed, you know, to a good approximation, the amount of energy converted, which can be expressed in kilojoules. Iodine contributes to normal energy-yielding metabolism — In accordance with Regulation (EU) No 432/2012.

Nerve tissue and the third register entry

Nerve cells also carry these receptors in their nucleus. The element itself, however, does not reach them as an ion, but exclusively as a component of the messenger substances that cross the boundary into nerve tissue. There they act on the formation of cell processes, on the sheathing of nerve fibers and on the cells' supply of enzymes. The third sentence rests on this basis: Iodine contributes to normal cognitive function — In accordance with Regulation (EU) No 432/2012. It describes a contribution to a normal function, not an improvement in memory, attention or speed of thinking.

Quoted, not paraphrased

The three sentences in their original wording. They stand on their own and cannot be combined into a broader statement.

  1. “Iodine contributes to normal energy-yielding metabolism” In accordance with Regulation (EU) No. 432/2012
  2. “Iodine contributes to the normal function of the thyroid gland” In accordance with Regulation (EU) No. 432/2012
  3. “Iodine contributes to normal cognitive function” In accordance with Regulation (EU) No. 432/2012

Answers, kept short

Why does the sentence about energy-yielding metabolism also appear for other minerals?

Because the Union list is organized by nutrient, not by wording. Several elements have gone through their own scientific opinion on this subject area and therefore carry an identically worded sentence. This means neither that they do the same thing nor that they can replace one another; each entry stands on its own and belongs solely to the element named in it.

Does this publication contain information about thyroid diseases?

No, and that is not an oversight. Statements about diseases are legally excluded for foods, and they would also be inappropriate here from a professional standpoint. The authorized claims are aimed at the general population without a diagnosis. Anyone who knows of or suspects a disease of this organ belongs in the care of a physician.

Who applied for the three sentences, and since when have they applied?

Applications for the authorization of a claim are submitted by member states, associations or individual companies. They are scientifically assessed, and the Commission then decides whether to include them in the Union list. For this element, that happened with the regulation that came into force in 2012; the underlying scientific opinions date from the years before. The wording has remained unchanged since then.

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The purchased file picks up where this page ends: it extends the content tables across six food groups, sets the intake values of European and German-speaking expert bodies side by side in a single overview, and notes the survey year for each value.

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